As the U.S. organ donor waiting list nears a record 100,000 and an average of seven Americans die every day waiting for an organ that never comes, solving the U.S. organ shortage takes on new urgency. Matas and Hippen will argue that the shortage could be solved by lifting the U.S. prohibition on the sale of human organs. Delmonico and Crowe will argue that the legalization of organ sales would do more harm than good. Matas will present his model for a regulated organ market described in his recent Cato study “A Gift of Life Deserves Compensation.” And Hippen will present his observations on why Iran is the only country in the world without an organ shortage, the subject of his forthcoming study.